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KMID : 1190620080040020061
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Journal of the Korean Wound Care Society
2008 Volume.4 No. 2 p.61 ~ p.68
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Hydrophilization of Biodegradable Dual Pore Scaffolds and Its Effect on Osteoblast Adhesion
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Park Kwi-Deok
Han Dong-Keun
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Abstract
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Biodegradable dual pore polymer scaffolds were successfully fabricated in this study. A mixture of dioxane/water was used as a solvent system. After the gas foaming process was complete, the resultant scaffolds carried a dual pore architecture, in which two distinct pore sizes were present in the same matrix: large pores in 200∼300?m and small ones in 5∼20?m. The volume ratio of dioxane/water in 87/13 (v/v) was optimal condition in producing a dual pore network. Followed by surface modifications utilizing plasma treatment and acrylic acid (AA) grafting, significantly reduced water contact angles and increased surface oxygen level were identified for the AA-grafted polymer substrate. Surface morphology was barely affected from the modifiation. When osteoblasts were seeded onto AA-grafted poly (L-lactic acid) (PLLA) scaffolds and cultured for 4 weeks, the surface-modified scaffolds were more effective in the improvement of cell adhesion and proliferation as compared to PLLA control. The present study suggests that the surface-modified dual pore scaffolds can be feasible in tissue engineering applications for better cell seeding, attachment, and growth. (J Korean Wound Management Soc 2008;4:61-68)
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KEYWORD
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Tissue engineering, Dual pore polymer scaffold, Acrylic acid, Hydrophilization, Osteoblasts
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